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Sources of controversy Are doctors providing accurate information to each other and to patients?
- What are the best sources of information?
- How much weight does one put on recommendations from various sources?
Can surgery be performed differently to improve the outcome?
- Timing
- Technique
Does this condition require surgical correction? Who is the best person/people to make this decision, and at what age? What is the best way to handle sex assignment in various conditions of ambiguity?
- What are best criteria for best choice?
refs
Glycosylation is the attachment by molecular bonding of glucose to a larger molecule, usually a [[protein]. This process occurs in animal tissues in variety of both normal and abnormal contexts, involving a wide variety of proteins.
One of the most common contexts in which glycosylation is discussed is diabetes mellitus, a disease charaterized by high levels of glucose in blood and tissues much of the time. This type of glycosylation is spontaneous and non-enzymatic, and described as an Amadori reaction. The amount of glycosylation depends on the amount of glucose present and duration of exposure (i.e., the "lifetime" of the protein). Glycosylation alters the physical properties of some proteins, and this may contribute to tissue damage from chronic hyperglycemia and the subsequent long-term microvascular complications of diabetes.
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In diabetes care, and in medical practice in general, the most well-known glycosylated protein is hemoglobin. Glycosylated hemoglobin is also called glycohemoglobin and hemoglobin A1c in clinical contexts (though there are minor technical distinctions between the terms). The percentage of hemoglobin that is glycosylated reflects the average level of glucose in the blood over the preceding 2-3 months, and is the most important measure of glycemic control in diabetes management.