V-Src

Tyrosine-protein kinase transforming protein Src
Identifiers
OrganismRous sarcoma virus
Symbolv-src
Alt. symbolspp60v-src
Entrez1491925
RefSeq (Prot)NP_056888.1
UniProtP00526
Other data
EC number2.7.10.2
Chromosomeviral: 0.01 - 0.01 Mb
Search for
StructuresSwiss-model
DomainsInterPro

v-Src is a gene found in Rous sarcoma virus (RSV) that encodes a tyrosine kinase that causes a type of cancer in chickens.

The src gene is oncogenic as it triggers uncontrolled growth in abnormal host cells. It was the first retroviral oncogene to be discovered.[1] The src gene was taken up by RSV and incorporated into its genome[2] conferring it with the advantage of being able to stimulate uncontrolled mitosis of host cells, providing abundant cells for fresh infection.

The src gene is not essential for RSV proliferation but it greatly increases virulence when present.

  1. ^ Vogt PK (September 2012). "Retroviral oncogenes: a historical primer". Nat. Rev. Cancer. 12 (9): 639–48. doi:10.1038/nrc3320. PMC 3428493. PMID 22898541.
  2. ^ Swanstrom, R; Parker, R C; Varmus, H E; Bishop, J M (May 1983). "Transduction of a cellular oncogene: the genesis of Rous sarcoma virus". Proceedings of the National Academy of Sciences. 80 (9): 2519–2523. doi:10.1073/pnas.80.9.2519. PMC 393857. PMID 6302692.