V. Sasisekharan

V. Sasisekharan
Born (1933-06-28) 28 June 1933 (age 91)
India
NationalityIndian
Alma mater
Known forConformation of biopolymers
Awards1978 Shanti Swarup Bhatnagar Prize
1981 FICCI Award
1983 INSA J. C. Bose Medal
1985 Hari Om Ashram J. C. Bose Award
1987 Watumull Honor Summus Medal
1989 Om Prakash Bhasin Award
Scientific career
Fields
Institutions

Viswanathan Sasisekharan (born 1933) is an Indian biophysicist known for his work on the structure and conformation of biopolymers. He introduced the use of torsion angles to describe polypeptide and protein conformation, a central principle of the (φ, ψ) plot (later known as the Ramachandran plot).[1][2][3] Additionally, he was the first to introduce alternative models of DNA structure that provided insights beyond the standard double helix model.[4][5][6] For his contributions to the biological sciences, he was awarded the Shanti Swarup Bhatnagar Prize for Science and Technology, one of India’s highest science awards, in 1978.[7]

  1. ^ Sasisekharan, V (1962). Ramanathan, N (ed.). Stereochemical Criteria for Polypeptide and Protein Structures. New York: John Wiley. pp. 39–77. {{cite book}}: |work= ignored (help)
  2. ^ Ramachandran, G. N.; Ramakrishnan, C.; Sasisekharan, V. (1963). "Stereochemistry of polypeptide chain configurations". Journal of Molecular Biology. 7: 95–99. doi:10.1016/s0022-2836(63)80023-6. ISSN 0022-2836. PMID 13990617.
  3. ^ Hollingsworth, Scott A.; Karplus, P. Andrew (1 October 2010). "A fresh look at the Ramachandran plot and the occurrence of standard structures in proteins". BioMolecular Concepts. 1 (3–4): 271–283. doi:10.1515/bmc.2010.022. ISSN 1868-503X. PMC 3061398. PMID 21436958.
  4. ^ Sasisekharan, V; Pattabiraman, N (1976). "Double stranded polynucleotides: two typical alternative conformations for nucleic acids" (PDF). Current Science. 45: 779–783. Archived from the original (PDF) on 13 December 2019. Retrieved 21 June 2020.
  5. ^ Sasisekharan, V.; Pattabiraman, N. (1978). "Structure of DNA predicted from stereochemistry of nucleoside derivatives". Nature. 275 (5676): 159–162. Bibcode:1978Natur.275..159S. doi:10.1038/275159a0. ISSN 0028-0836. PMID 692688. S2CID 4145327.
  6. ^ Sasisekharan, V.; Pattabiraman, N.; Gupta, G. (1 September 1978). "Some implications of an alternative structure for DNA". Proceedings of the National Academy of Sciences. 75 (9): 4092–4096. Bibcode:1978PNAS...75.4092S. doi:10.1073/pnas.75.9.4092. ISSN 0027-8424. PMC 336057. PMID 279899.
  7. ^ "View Bhatnagar Awardees". Shanti Swarup Bhatnagar Prize. 2016. Retrieved 19 September 2016.