VEGFR1

FLT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FLT, 1QSV, 1QSZ, 1QTY, 1RV6, 2XAC, 3HNG, 4CKV, 4CL7, 5EX3
Identifiers
Aliases	FLT1, FLT, FLT-1, VEGFR-1, VEGFR1, fms related tyrosine kinase 1, vascular endothelial growth factor receptor 1, fms related receptor tyrosine kinase 1
External IDs	OMIM: 165070; MGI: 95558; HomoloGene: 134179; GeneCards: FLT1; OMA:FLT1 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	28,495,145 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	147,662,821 bp
RNA expression pattern
	Top expressed in
	pericardium; ; placenta; ; endothelial cell; ; right ventricle; ; myocardium of left ventricle; ; dorsal motor nucleus of vagus nerve; ; cardia; ; thyroid gland; ; left lobe of thyroid gland; ; internal globus pallidus;
	Top expressed in
	right lung; ; right lung lobe; ; internal carotid artery; ; myocardium of ventricle; ; muscle of thigh; ; external carotid artery; ; umbilical cord; ; cardiac muscle tissue of left ventricle; ; islet of Langerhans; ; substantia nigra;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	vascular endothelial growth factor-activated receptor activity; transferase activity; nucleotide binding; protein kinase activity; placental growth factor-activated receptor activity; kinase activity; protein binding; transmembrane receptor protein tyrosine kinase activity; protein tyrosine kinase activity; ATP binding; growth factor binding; vascular endothelial growth factor binding;
Cellular component	cytoplasm; integral component of membrane; endosome; focal adhesion; membrane; receptor complex; integral component of plasma membrane; extracellular region; extracellular space; plasma membrane; actin cytoskeleton;
Biological process	positive regulation of vascular endothelial growth factor receptor signaling pathway; cell differentiation; blood vessel morphogenesis; vascular endothelial growth factor receptor-1 signaling pathway; positive regulation of MAP kinase activity; monocyte chemotaxis; positive regulation of phospholipase C activity; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor signaling pathway; phosphorylation; positive regulation of angiogenesis; positive regulation of phosphatidylinositol 3-kinase activity; multicellular organism development; chemotaxis; protein phosphorylation; vascular endothelial growth factor receptor signaling pathway; embryonic morphogenesis; angiogenesis; protein autophosphorylation; positive regulation of phosphatidylinositol 3-kinase signaling; peptidyl-tyrosine phosphorylation; cellular response to vascular endothelial growth factor stimulus; cell migration; positive regulation of MAPK cascade; positive regulation of cell population proliferation; positive regulation of cell migration; sprouting angiogenesis; positive regulation of ERK1 and ERK2 cascade; negative regulation of vascular endothelial cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	2321
	14254
	ENSG00000102755
	ENSMUSG00000029648
	P17948
	P35969
	NM_001159920; NM_001160030; NM_001160031; NM_002019
	NM_010228; NM_001363135
	NP_001153392; NP_001153502; NP_001153503; NP_002010
	NP_034358; NP_001350064
	Wikidata
View/Edit Human	View/Edit Mouse

Vascular endothelial growth factor receptor 1 is a protein that in humans is encoded by the FLT1 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000102755 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029648 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shibuya M, Yamaguchi S, Yamane A, Ikeda T, Tojo A, Matsushime H, Sato M (April 1990). "Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family". Oncogene. 5 (4): 519–24. PMID 2158038.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000102755 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029648 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2158038-5] Shibuya M, Yamaguchi S, Yamane A, Ikeda T, Tojo A, Matsushime H, Sato M (April 1990). "Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family". Oncogene. 5 (4): 519–24. PMID 2158038.

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