VEGF receptor

VEGF receptor
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
Identifiers
SymbolVEGF
InterProIPR009135
Membranome1335
Identifiers
SymbolFLT1
Alt. symbolsFLT
NCBI gene2321
HGNC3763
OMIM165070
RefSeqNM_002019
UniProtP17948
Other data
EC number2.7.1.112
LocusChr. 13 q12
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StructuresSwiss-model
DomainsInterPro
kinase insert domain receptor (a type III receptor tyrosine kinase)
Identifiers
SymbolKDR
Alt. symbolsFLK1, VEGFR, VEGFR2, CD309
NCBI gene3791
HGNC6307
OMIM191306
RefSeqNM_002253
UniProtP35968
Other data
EC number2.7.1.112
LocusChr. 4 q11-q12
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StructuresSwiss-model
DomainsInterPro
fms-related tyrosine kinase 4
Identifiers
SymbolFLT4
Alt. symbolsVEGFR3, PCL
NCBI gene2324
HGNC3767
OMIM136352
RefSeqNM_002020
UniProtP35916
Other data
EC number2.7.1.112
LocusChr. 5 q34-q35
Search for
StructuresSwiss-model
DomainsInterPro

VEGF receptors (VEGFRs) are receptors for vascular endothelial growth factor (VEGF).[1][2] There are three main subtypes of VEGFR, numbered 1, 2 and 3. Depending on alternative splicing, they may be membrane-bound (mbVEGFR) or soluble (sVEGFR).[3]

Inhibitors of VEGFR are used in the treatment of cancer.

  1. ^ Holmes K, Roberts OL, Thomas AM, Cross MJ (October 2007). "Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition". Cellular Signalling. 19 (10): 2003–12. doi:10.1016/j.cellsig.2007.05.013. PMID 17658244.
  2. ^ Stuttfeld E, Ballmer-Hofer K (September 2009). "Structure and function of VEGF receptors". IUBMB Life. 61 (9): 915–22. doi:10.1002/iub.234. PMID 19658168. S2CID 10190107.
  3. ^ Fujita N, Imai J, Suzuki T, Yamada M, Ninomiya K, Miyamoto K, et al. (July 2008). "Vascular endothelial growth factor-A is a survival factor for nucleus pulposus cells in the intervertebral disc". Biochemical and Biophysical Research Communications. 372 (2): 367–72. doi:10.1016/j.bbrc.2008.05.044. PMID 18492486.