VISTA (protein)

VSIR
Identifiers
Aliases	VSIR, B7-H5, B7H5, GI24, PP2135, SISP1, DD1alpha, VISTA, C10orf54, chromosome 10 open reading frame 54, PD-1H, V-set immunoregulatory receptor, Dies1
External IDs	OMIM: 615608; MGI: 1921298; HomoloGene: 81923; GeneCards: VSIR; OMA:VSIR - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	71,773,520 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	60,208,463 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; blood; ; bone marrow cells; ; spleen; ; appendix; ; right lung; ; tibial nerve; ; apex of heart; ; left uterine tube;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; mesenteric lymph nodes; ; tibiofemoral joint; ; decidua; ; spleen; ; white adipose tissue; ; subcutaneous adipose tissue; ; blood; ; ankle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	identical protein binding; enzyme binding; endopeptidase activator activity;
Cellular component	integral component of membrane; membrane; plasma membrane;
Biological process	positive regulation of gene expression; positive regulation of endopeptidase activity; positive regulation of cell migration; zymogen activation; negative regulation of interferon-gamma production; negative regulation of interleukin-10 production; negative regulation of interleukin-17 production; negative regulation of tumor necrosis factor production; positive regulation of regulatory T cell differentiation; positive regulation of collagen catabolic process; negative regulation of CD4-positive, alpha-beta T cell proliferation; negative regulation of CD8-positive, alpha-beta T cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	64115
	74048
	ENSG00000107738
	ENSMUSG00000020101
	Q9H7M9
	Q9D659
	NM_022153
	NM_001159572; NM_028732
	NP_071436
	NP_001153044; NP_083008
	Wikidata
View/Edit Human	View/Edit Mouse

V-domain Ig suppressor of T cell activation (VISTA) is a type I transmembrane protein that functions as an immune checkpoint and is encoded by the VSIR gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000107738 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020101 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Le Mercier I, Lines JL, Noelle RJ (August 2015). "Beyond CTLA-4 and PD-1, the Generation Z of Negative Checkpoint Regulators". Frontiers in Immunology. 6: 418. doi:10.3389/fimmu.2015.00418. PMC 4544156. PMID 26347741.
^ Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, et al. (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
^ "Entrez Gene: C10orf54 chromosome 10 open reading frame 54".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000107738 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020101 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid26347741-5] Le Mercier I, Lines JL, Noelle RJ (August 2015). "Beyond CTLA-4 and PD-1, the Generation Z of Negative Checkpoint Regulators". Frontiers in Immunology. 6: 418. doi:10.3389/fimmu.2015.00418. PMC 4544156. PMID 26347741.

[pmid12975309-6] Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, et al. (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.

[entrez-7] "Entrez Gene: C10orf54 chromosome 10 open reading frame 54".

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