VLDL receptor

VLDLR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1V9U, 3DPR
Identifiers
Aliases	VLDLR, CAMRQ1, CARMQ1, CHRMQ1, VLDLRCH, VLDL-R, very low density lipoprotein receptor
External IDs	OMIM: 192977; MGI: 98935; HomoloGene: 443; GeneCards: VLDLR; OMA:VLDLR - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p24.2 Start 2,621,182 bp[1] End 2,660,056 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 C1|19 21.77 cM Start 27,216,484 bp[2] End 27,254,231 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right ventricle left ovary right ovary myocardium of left ventricle islet of Langerhans cardiac muscle tissue of right atrium right auricle gingival epithelium biceps brachii body of pancreas Top expressed in decidua retinal pigment epithelium ankle vas deferens right ventricle molar sternocleidomastoid muscle digastric muscle body of femur temporal muscle More reference expression data BioGPS n/a
Gene ontology Molecular function low-density lipoprotein particle receptor activity reelin receptor activity calcium ion binding apolipoprotein binding protein binding very-low-density lipoprotein particle binding calcium-dependent protein binding very-low-density lipoprotein particle receptor activity cargo receptor activity Cellular component integral component of membrane membrane receptor complex plasma membrane very-low-density lipoprotein particle clathrin-coated pit extracellular space lysosomal membrane Biological process steroid metabolic process lipid transport endocytosis dendrite morphogenesis lipid metabolism glycoprotein transport cholesterol metabolic process negative regulation of transcription by RNA polymerase II memory positive regulation of dendrite development receptor-mediated endocytosis nervous system development ventral spinal cord development reelin-mediated signaling pathway transport signal transduction positive regulation of protein kinase activity axon guidance low-density lipoprotein particle receptor catabolic process very-low-density lipoprotein particle clearance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7436 22359 Ensembl ENSG00000147852 ENSMUSG00000024924 UniProt P98155 P98156 RefSeq (mRNA) NM_001018056 NM_003383 NM_001322225 NM_001322226 NM_001161420 NM_013703 NM_001347441 RefSeq (protein) NP_001018066 NP_001309154 NP_001309155 NP_003374 NP_001154892 NP_001334370 NP_038731 Location (UCSC) Chr 9: 2.62 – 2.66 Mb Chr 19: 27.22 – 27.25 Mb PubMed search [3] [4]
Wikidata
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The very-low-density-lipoprotein receptor (VLDLR) is a transmembrane lipoprotein receptor of the low-density-lipoprotein (LDL) receptor family. VLDLR shows considerable homology with the members of this lineage. Discovered in 1992 by T. Yamamoto, VLDLR is widely distributed throughout the tissues of the body, including the heart, skeletal muscle, adipose tissue, and the brain, but is absent from the liver.^[5] This receptor has an important role in cholesterol uptake, metabolism of apolipoprotein E-containing triacylglycerol-rich lipoproteins, and neuronal migration in the developing brain. In humans, VLDLR is encoded by the VLDLR gene. Mutations of this gene may lead to a variety of symptoms and diseases, which include type I lissencephaly, cerebellar hypoplasia, and atherosclerosis.