VPS26A

VPS26A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesVPS26A, HB58, Hbeta58, PEP8A, VPS26, VPS26 retromer complex component A, VPS26, retromer complex component A
External IDsOMIM: 605506; MGI: 1353654; HomoloGene: 68420; GeneCards: VPS26A; OMA:VPS26A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001035260
NM_004896
NM_001318944
NM_001318945
NM_001318946

NM_001113355
NM_133672
NM_001358543

RefSeq (protein)

NP_001030337
NP_001305873
NP_001305874
NP_001305875
NP_004887

NP_001106826
NP_598433
NP_001345472

Location (UCSC)Chr 10: 69.12 – 69.17 MbChr 10: 62.29 – 62.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Vacuolar protein sorting-associated protein 26A is a protein that in humans is encoded by the VPS26A gene.[5][6][7]

This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms.[7]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000122958Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020078Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lee JJ, Radice G, Perkins CP, Costantini F (Aug 1992). "Identification and characterization of a novel, evolutionarily conserved gene disrupted by the murine H beta 58 embryonic lethal transgene insertion". Development. 115 (1): 277–88. doi:10.1242/dev.115.1.277. PMID 1638986.
  6. ^ Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Aug 1998). "Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc Natl Acad Sci U S A. 95 (14): 8175–80. Bibcode:1998PNAS...95.8175M. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
  7. ^ a b "Entrez Gene: VPS26A vacuolar protein sorting 26 homolog A (S. pombe)".