Vacuolar protein sorting ortholog 35 (VPS35) is a protein involved in autophagy and is implicated in neurodegenerative diseases, such as Parkinson's disease (PD) and Alzheimer's disease (AD).[1][2][3][4][5] VPS35 is part of a complex called the retromer, which is responsible for transporting select cargo proteins between vesicular structures (e.g., endosomes, lysosomes, vacuoles) and the Golgi apparatus.[1][6][7][8] Mutations in the VPS35 gene (VPS35) cause aberrant autophagy, where cargo proteins fail to be transported and dysfunctional or unnecessary proteins fail to be degraded.[5][6] There are numerous pathways affected by altered VPS35 levels and activity, which have clinical significance in neurodegeneration.[1][2][3][4][5] There is therapeutic relevance for VPS35, as interventions aimed at correcting VPS35 function are in speculation.[5][9][10]
^ abFollett J, Bugarcic A, Collins BM, Teasdale RD (2017-07-01). "Retromer's Role in Endosomal Trafficking and Impaired Function in Neurodegenerative Diseases". Current Protein & Peptide Science. 18 (7): 687–701. doi:10.2174/1389203717666160311121246. PMID26965691.
^ abcdTrousdale C, Kim K (November 2015). "Retromer: Structure, function, and roles in mammalian disease". European Journal of Cell Biology. 94 (11): 513–21. doi:10.1016/j.ejcb.2015.07.002. PMID26220253.