Valganciclovir

Valganciclovir
Clinical data
Trade namesValcyte, Valcip, others
AHFS/Drugs.comMonograph
MedlinePlusa605021
License data
Pregnancy
category
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability60%
Protein binding1–2%
MetabolismHydrolysed to ganciclovir
Elimination half-life4 hours
ExcretionKidney
Identifiers
  • 2-[(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)methoxy]-3-hydroxypropyl-(2S)-2-amino-3-methylbutanoate
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
NIAID ChemDB
PDB ligand
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC14H22N6O5
Molar mass354.367 g·mol−1
3D model (JSmol)
  • O=C(OCC(OCn1c2N\C(=N/C(=O)c2nc1)N)CO)[C@@H](N)C(C)C
  • InChI=1S/C14H22N6O5/c1-7(2)9(15)13(23)24-4-8(3-21)25-6-20-5-17-10-11(20)18-14(16)19-12(10)22/h5,7-9,21H,3-4,6,15H2,1-2H3,(H3,16,18,19,22)/t8?,9-/m0/s1 checkY
  • Key:WPVFJKSGQUFQAP-GKAPJAKFSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Valganciclovir, sold under the brand name Valcyte among others, is an antiviral medication used to treat cytomegalovirus (CMV) infection in those with HIV/AIDS or following organ transplant.[3] It is often used long term as it only suppresses rather than cures the infection.[3] Valganciclovir is taken by mouth.[3]

Common side effects include abdominal pain, headaches, trouble sleeping, nausea, fever, and low blood cell counts.[3] Other side effects may include infertility and kidney problems.[3] When used during pregnancy, it causes birth defects in some animals.[3] Valganciclovir is the L-valyl ester of ganciclovir and works when broken down into ganciclovir by the intestine and liver.[3]

Valganciclovir was approved for medical use in 2001.[4] It is on the World Health Organization's List of Essential Medicines.[5][6] In 2017, a generic version was approved.[7]

  1. ^ a b "Valcyte® (valganciclovir hydrochloride)". Australian Product Information. MedAdvisor International Pty Ltd. Retrieved 2023-08-10.
  2. ^ Cite error: The named reference Valcyte FDA label was invoked but never defined (see the help page).
  3. ^ a b c d e f g "Valganciclovir Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 29 November 2016. Retrieved 28 November 2016.
  4. ^ Long SS, Pickering LK, Prober CG (2012). Principles and Practice of Pediatric Infectious Disease. Elsevier Health Sciences. p. 1502. ISBN 978-1-4377-2702-9. Archived from the original on 2016-11-29.
  5. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  6. ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
  7. ^ "Generic Valcyte Availability". Drugs.com. Archived from the original on 17 March 2017. Retrieved 25 June 2017.