Valnoctamide

Valnoctamide
Skeletal formula of valnoctamide
Names
Preferred IUPAC name
2-Ethyl-3-methylpentanamide[1]
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.021.849 Edit this at Wikidata
EC Number
  • 224-033-7
KEGG
MeSH valnoctamide
RTECS number
  • YV5950000
UNII
  • InChI=1S/C8H17NO/c1-4-6(3)7(5-2)8(9)10/h6-7H,4-5H2,1-3H3,(H2,9,10) checkY
    Key: QRCJOCOSPZMDJY-UHFFFAOYSA-N checkY
  • CCC(C)C(CC)C(N)=O
Properties
C8H17NO
Molar mass 143.230 g·mol−1
Appearance White crystals
log P 1.885
Pharmacology
N05CM13 (WHO)
  • Intravenous
  • Oral
Pharmacokinetics:
94%
Hepatic
10 hours
Hazards
GHS labelling:
GHS07: Exclamation mark
Warning
H302
Lethal dose or concentration (LD, LC):
760 mg kg−1 (oral, rat)
Related compounds
Related alkanamides
Valpromide
Related compounds
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Valnoctamide (INN, USAN) has been used in France as a sedative-hypnotic since 1964.[2] It is a structural isomer of valpromide, a valproic acid prodrug; unlike valpromide, however, valnoctamide is not transformed into its homologous acid, valnoctic acid, in vivo.[3]

  1. ^ "valnoctamide - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 26 March 2005. Identification and Related Records. Retrieved 20 February 2012.
  2. ^ Harl, F. M. (March 1964). "[Clinical Study Of Valnoctamide On 70 Neuropsychiatric Clinic Patients Undergoing Ambulatory Treatment]". La Presse Médicale (in French). 72: 753–754. PMID 14119722.
  3. ^ Haj-Yehia, Abdullah; Meir Bialer (August 1989). "Structure-pharmacokinetic relationships in a series of valpromide derivatives with antiepileptic activity". Pharmaceutical Research. 6 (8): 683–689. doi:10.1023/A:1015934321764. PMID 2510141. S2CID 21531402.