Vandetanib

Vandetanib
Clinical data
Trade namesCaprelsa
Other namesZD6474
AHFS/Drugs.comMonograph
MedlinePlusa611037
License data
Pregnancy
category
  • AU: D
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding90–96%
MetabolismCYP3A4, FMO1, FMO3
Elimination half-life19 days (mean)[2]
Excretion44% faeces, 25% urine
Identifiers
  • N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB ligand
CompTox Dashboard (EPA)
ECHA InfoCard100.195.611 Edit this at Wikidata
Chemical and physical data
FormulaC22H24BrFN4O2
Molar mass475.362 g·mol−1
3D model (JSmol)
  • CN1CCC(CC1)COc2cc3c(cc2OC)c(ncn3)Nc4ccc(cc4F)Br
  • InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27) checkY
  • Key:UHTHHESEBZOYNR-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Vandetanib, sold under the brand name Caprelsa, is an anti-cancer medication that is used for the treatment of certain tumours of the thyroid gland. It acts as a kinase inhibitor of a number of cell receptors, mainly the vascular endothelial growth factor receptor, the epidermal growth factor receptor, and the RET-tyrosine kinase.[4][5] The drug was developed by AstraZeneca[2] who later sold the rights to Sanofi in 2015.[6][7]

  1. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
  2. ^ a b c Cite error: The named reference USlabel was invoked but never defined (see the help page).
  3. ^ "Caprelsa EPAR". European Medicines Agency (EMA). 17 February 2012. Retrieved 26 September 2024.
  4. ^ "Definition of vandetanib". NCI Drug Dictionary. National Cancer Institute. 2011-02-02.
  5. ^ Cite error: The named reference Drugs.com was invoked but never defined (see the help page).
  6. ^ "AZ sells rare cancer drug to Sanofi". PMLive. 2015-07-27. Retrieved 2021-01-26.
  7. ^ "Genzyme to Buy Caprelsa from AstraZeneca for Up to $300M". GEN - Genetic Engineering and Biotechnology News. 2015-07-27. Retrieved 2021-01-26.