Vascular endothelial growth factor C

VEGFC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2X1W, 2X1X, 4BSK
Identifiers
Aliases	VEGFC, Flt4-L, LMPH1D, VRP, vascular endothelial growth factor C, LMPHM4
External IDs	OMIM: 601528; MGI: 109124; HomoloGene: 3962; GeneCards: VEGFC; OMA:VEGFC - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q34.3 Start 176,683,538 bp[1] End 176,792,922 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 B1.3 Start 54,530,641 bp[2] End 54,640,131 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium right lobe of thyroid gland left lobe of thyroid gland testicle right lung decidua parietal pleura visceral pleura pericardium subcutaneous adipose tissue Top expressed in external carotid artery internal carotid artery semi-lunar valve migratory enteric neural crest cell left lung lobe abdominal wall endocardial cushion aortic valve conjunctival fornix stroma of bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chemoattractant activity protein binding growth factor activity vascular endothelial growth factor receptor 3 binding vascular endothelial growth factor receptor binding Cellular component extracellular region membrane platelet alpha granule lumen extracellular space Biological process negative regulation of cell population proliferation positive regulation of neuroblast proliferation positive regulation of protein secretion substrate-dependent cell migration signal transduction positive regulation of protein autophosphorylation multicellular organism development morphogenesis of embryonic epithelium positive regulation of cell-matrix adhesion positive regulation of mast cell chemotaxis positive regulation of blood vessel endothelial cell migration positive regulation of cell division induction of positive chemotaxis platelet degranulation positive regulation of peptidyl-tyrosine phosphorylation negative regulation of blood pressure positive regulation of cell population proliferation positive regulation of lymphangiogenesis regulation of vascular endothelial growth factor receptor signaling pathway cell differentiation positive regulation of epithelial cell proliferation animal organ morphogenesis positive chemotaxis angiogenesis response to hypoxia positive regulation of endothelial cell proliferation positive regulation of angiogenesis cellular response to leukemia inhibitory factor vascular endothelial growth factor receptor signaling pathway regulation of signaling receptor activity positive regulation of protein phosphorylation sprouting angiogenesis vascular endothelial growth factor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7424 22341 Ensembl ENSG00000150630 ENSMUSG00000031520 UniProt P49767 P97953 RefSeq (mRNA) NM_005429 NM_009506 RefSeq (protein) NP_005420 NP_033532 Location (UCSC) Chr 4: 176.68 – 176.79 Mb Chr 8: 54.53 – 54.64 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Vascular endothelial growth factor C (VEGF-C) is a protein that is a member of the platelet-derived growth factor / vascular endothelial growth factor (PDGF/VEGF) family. It is encoded in humans by the VEGFC gene, which is located on chromosome 4q34.^[5]