Vascular endothelial growth inhibitor

TNFSF15
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2O0O, 2QE3, 2RE9, 2RJK, 2RJL, 3K51, 3MI8
Identifiers
Aliases	TNFSF15, TL1, TL1A, VEGI, VEGI192A, Vascular endothelial growth inhibitor, TNLG1B, tumor necrosis factor superfamily member 15, TNF superfamily member 15
External IDs	OMIM: 604052; MGI: 2180140; HomoloGene: 3755; GeneCards: TNFSF15; OMA:TNFSF15 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	114,806,039 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	63,663,350 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; jejunal mucosa; ; duodenum; ; germinal epithelium; ; visceral pleura; ; palpebral conjunctiva; ; pancreatic ductal cell; ; parotid gland; ; urethra; ; mucosa of ileum;
	Top expressed in
	embryo; ; right kidney; ; lung; ; human kidney; ; duodenum; ; ileum; ; renal cortex; ; jejunum; ; colon; ; zone of skin;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	tumor necrosis factor receptor binding; cytokine activity; signaling receptor binding; protein binding;
Cellular component	integral component of membrane; extracellular region; plasma membrane; integral component of plasma membrane; membrane; intracellular anatomical structure; extracellular space;
Biological process	tumor necrosis factor-mediated signaling pathway; activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of NF-kappaB-inducing kinase activity; immune response; apoptotic process; signal transduction; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	9966
	326623
	ENSG00000181634
	ENSMUSG00000050395
	O95150
	Q5UBV8
	NM_005118; NM_001204344
	NM_177371
	NP_001191273; NP_005109
	NP_796345
	Wikidata
View/Edit Human	View/Edit Mouse

Vascular endothelial growth inhibitor (VEGI), also known as TNF-like ligand 1A (TL1A) and TNF superfamily member 15 (TNFSF15), is protein that in humans is encoded by the TNFSF15 gene. VEGI is an anti-angiogenic protein.^[5] It belongs to tumor necrosis factor (ligand) superfamily, where it is member 15.^[6] It is the sole known ligand for death receptor 3,^[7] and it can also be recognized by decoy receptor 3.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000181634 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050395 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hoffmann R, Valencia A (Jul 2004). "A gene network for navigating the literature". Nature Genetics. 36 (7): 664. doi:10.1038/ng0704-664. PMID 15226743.
^ "Entrez Gene: TNFSF15 tumor necrosis factor (ligand) superfamily, member 15".
^ Wang EC (Sep 2012). "On death receptor 3 and its ligands…". Immunology. 137 (1): 114–116. doi:10.1111/j.1365-2567.2012.03606.x. PMC 3449252. PMID 22612445.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000181634 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000050395 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Hoffmann R, Valencia A (Jul 2004). "A gene network for navigating the literature". Nature Genetics. 36 (7): 664. doi:10.1038/ng0704-664. PMID 15226743.

[entrez-6] "Entrez Gene: TNFSF15 tumor necrosis factor (ligand) superfamily, member 15".

[7] Wang EC (Sep 2012). "On death receptor 3 and its ligands…". Immunology. 137 (1): 114–116. doi:10.1111/j.1365-2567.2012.03606.x. PMC 3449252. PMID 22612445.

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