Vasoactive intestinal peptide

VIP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesVIP, vasoactive intestinal peptide, PHM27
External IDsOMIM: 192320; MGI: 98933; HomoloGene: 2539; GeneCards: VIP; OMA:VIP - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003381
NM_194435

NM_011702
NM_001313969

RefSeq (protein)

NP_003372
NP_919416

Location (UCSC)Chr 6: 152.75 – 152.76 MbChr 10: 5.59 – 5.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Vasoactive intestinal peptide, also known as vasoactive intestinal polypeptide or VIP, is a peptide hormone that is vasoactive in the intestine. VIP is a peptide of 28 amino acid residues that belongs to a glucagon/secretin superfamily, the ligand of class II G protein–coupled receptors.[5] VIP is produced in many tissues of vertebrates including the gut, pancreas, cortex, and suprachiasmatic nuclei of the hypothalamus in the brain.[6][7][8] VIP stimulates contractility in the heart, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gallbladder. In humans, the vasoactive intestinal peptide is encoded by the VIP gene.[9]

VIP has a half-life (t½) in the blood of about two minutes.[10]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000146469Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019772Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Umetsu Y, Tenno T, Goda N, Shirakawa M, Ikegami T, Hiroaki H (May 2011). "Structural difference of vasoactive intestinal peptide in two distinct membrane-mimicking environments". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1814 (5): 724–30. doi:10.1016/j.bbapap.2011.03.009. PMID 21439408.
  6. ^ Juhász T, Helgadottir SL, Tamás A, Reglődi D, Zákány R (April 2015). "PACAP and VIP signaling in chondrogenesis and osteogenesis" (PDF). Peptides. 66: 51–7. doi:10.1016/j.peptides.2015.02.001. hdl:2437/208376. PMID 25701761. S2CID 8300971.
  7. ^ Delgado M, Ganea D (July 2013). "Vasoactive intestinal peptide: a neuropeptide with pleiotropic immune functions". Amino Acids. 45 (1): 25–39. doi:10.1007/s00726-011-1184-8. PMC 3883350. PMID 22139413.
  8. ^ Fahrenkrug J (2010-01-01). "VIP and PACAP". Cellular Peptide Hormone Synthesis and Secretory Pathways. Results and Problems in Cell Differentiation. Vol. 50. pp. 221–34. doi:10.1007/400_2009_24. ISBN 978-3-642-11834-0. PMID 19859678.
  9. ^ Hahm SH, Eiden LE (December 1998). "Cis-regulatory elements controlling basal and inducible VIP gene transcription". Annals of the New York Academy of Sciences. 865 (1): 10–26. Bibcode:1998NYASA.865...10H. doi:10.1111/j.1749-6632.1998.tb11158.x. PMID 9927992. S2CID 24889373.
  10. ^ Henning RJ, Sawmiller DR (January 2001). "Vasoactive intestinal peptide: cardiovascular effects". Cardiovascular Research. 49 (1): 27–37. doi:10.1016/s0008-6363(00)00229-7. PMID 11121793.