Vasopressin (medication)

This article is about the medication. For the natural peptide, see Vasopressin.
Vasopressin
Clinical data
Pronunciation/ˌveɪzoʊˈprɛsɪn/
Trade namesVasostrict (USA), Reverpleg (FR), Empressin (GER), others
Other namesarginine vasopressin; argipressin
AHFS/Drugs.comMonograph
License data
Pregnancy
category
Routes of
administration		Intravenous (IV), intramuscular (IM), subcutaneous (SC)
ATC code
Physiological data
Source tissuesSupraoptic nucleus; Paraventricular nucleus of hypothalamus
Target tissuesSystem-wide
ReceptorsV1A, V1B, V2, OXTR
AgonistsFelypressin, Desmopressin
AntagonistsDiuretics
MetabolismPredominantly in the liver and kidneys
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: ℞-only
Pharmacokinetic data
Protein binding1%
MetabolismPredominantly in the liver and kidneys
Elimination half-life10-20 minutes
ExcretionUrine
Identifiers
  • 1-{[(4R,7S,10S,13S,16S,19R)-19-Amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-p rolyl-L-arginylglycinamide
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.003.669 Edit this at Wikidata
Chemical and physical data
FormulaC46H65N15O12S2
Molar mass1084.24 g·mol−1
3D model (JSmol)
Density1.6±0.1 g/cm3
  • c1ccc(cc1)C[C@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)Cc3ccc(cc3)O)N)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
  • InChI=1S/C46H65N15O12S2 /c47-27-22-74-75-23-33(45(73)61-17-5-9-34(61)44(72)56-28(8-4-16-53-46(51)52)39(67)54-21-37(50)65)60-43(71)32(20-36(49)64)59-40(68)29(14-15-35(48)63)55-41(69)31(18-24-6-2-1-3-7-24)58-42(70)30(57-38(27)66)19-25-10-12-26(62)13-11-25/h1-3,6-7,10-13,27-34,62H,4-5,8-9,14-23,47H2,(H2,48,63)(H2,49,64)(H2,50,65)(H,54,67)(H,55,69)(H,56,72)(H,57,66)(H,58,70)(H,59,68)(H,60,71)(H4,51,52,53)/t27-,28-,29-,30-,31-,32-,33-,34-/m0/s1 checkY
  • Key:KBZOIRJILGZLEJ-LGYYRGKSSA-N checkY

Vasopressin infusions are in use for septic shock patients not responding to fluid resuscitation or infusions of catecholamines (e.g., dopamine or norepinephrine) to increase the blood pressure while sparing the use of catecholamines. These argipressins have much shorter elimination half-life (around 20 minutes) than synthetic non-arginine vasopresines with much longer elimination half-life of many hours. Further, argipressins act on V1a, V1b, and V2 receptors which consequently lead to higher eGFR and lower vascular resistance in the lungs. A number of injectable arginine vasopressins are in clinical use in the United States and the European Union. Pitressin among others, is a medication most commonly used in the treatment of frequent urination, increased thirst, and dehydration such as that resulting from diabetes insipidus, which causes increased and diluted urine.[2][3] It is used to treat abdominal distension following some surgeries, and in stomach roentgenography.[3] Vasopressin is a hormone that affects the kidneys and reduces urine flow.[4]

Side effects may include stomach ache, vertigo, pale skin, flatulence, headache, or tremor.[3][4]

It is available as a generic medication.[5]

  1. ^ a b "Vasopressin Use During Pregnancy". Drugs.com. 22 January 2020. Retrieved 7 September 2020.
  2. ^ "Diabetes Insipidus". National Institute of Diabetes and Digestive and Kidney Diseases. October 2015. Retrieved 28 May 2017.
  3. ^ a b c "Pitressin (Injection)". Drugs.com. Retrieved 26 June 2017.
  4. ^ a b "Vasopressin (Injection Route)". mayoclinic.org. Retrieved 26 June 2017.
  5. ^ "Competitive Generic Therapy Approvals". U.S. Food and Drug Administration (FDA). 29 June 2023. Archived from the original on 29 June 2023. Retrieved 29 June 2023.