Vasopressin receptor 1A

AVPR1A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1YTV
Identifiers
Aliases	AVPR1A, AVPR V1a, AVPR1, V1aR, arginine vasopressin receptor 1A, Vasopressin receptor 1A, V1a vasopressin receptor, antidiuretic hormone receptor 1A, SCCL vasopressin subtype 1a receptor, V1-vascular vasopressin receptor vascular/hepatic-type arginine vasopressin receptor
External IDs	OMIM: 600821; MGI: 1859216; HomoloGene: 568; GeneCards: AVPR1A; OMA:AVPR1A - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	63,151,201 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	122,289,357 bp
RNA expression pattern
	Top expressed in
	left adrenal gland; ; left adrenal cortex; ; popliteal artery; ; tibial arteries; ; parietal pleura; ; right adrenal gland; ; skin of hip; ; right adrenal cortex; ; adipose tissue; ; abdominal fat;
	Top expressed in
	liver; ; suprachiasmatic nucleus; ; upper lip; ; skin of external ear; ; right kidney; ; left lobe of liver; ; urinary bladder; ; genital tubercle; ; maxillary prominence; ; intercostal muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; protein kinase C binding; peptide hormone binding; V1A vasopressin receptor binding; G protein-coupled receptor activity; peptide binding; protein binding; vasopressin receptor activity;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; cytoplasmic vesicle; endosome; plasma membrane;
Biological process	ejaculation; telencephalon development; negative regulation of female receptivity; cellular response to hormone stimulus; generation of precursor metabolites and energy; blood circulation; negative regulation of transmission of nerve impulse; cellular response to water deprivation; signal transduction; activation of phospholipase C activity; positive regulation of heart rate; positive regulation of systemic arterial blood pressure; response to corticosterone; myotube differentiation; positive regulation of prostaglandin biosynthetic process; positive regulation of blood pressure; positive regulation of cell growth; penile erection; positive regulation of cellular pH reduction; positive regulation of cell population proliferation; social behavior; grooming behavior; response to inorganic substance; calcium-mediated signaling; maternal aggressive behavior; positive regulation of glutamate secretion; response to organic substance; response to peptide; positive regulation of renal sodium excretion; positive regulation of cytosolic calcium ion concentration; G protein-coupled receptor signaling pathway; regulation of systemic arterial blood pressure by vasopressin; maternal behavior; positive regulation of vasoconstriction;
	Sources:Amigo / QuickGO
Orthologs
	552
	54140
	ENSG00000166148
	ENSMUSG00000020123
	P37288
	Q62463
	NM_000706
	NM_016847
	NP_000697
	NP_058543
	Wikidata
View/Edit Human	View/Edit Mouse

Vasopressin receptor 1A (V1AR), or arginine vasopressin receptor 1A (officially called AVPR1A) is one of the three major receptor types for vasopressin (AVPR1B and AVPR2 being the others), and is present throughout the brain, as well as in the periphery in the liver, kidney, and vasculature.^[5]

AVPR1A is also known as:

V1a vasopressin receptor
antidiuretic hormone receptor 1A
SCCL vasopressin subtype 1a receptor
V1-vascular vasopressin receptor AVPR1A
vascular/hepatic-type arginine vasopressin receptor

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166148 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020123 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Caldwell HK, Lee HJ, Macbeth AH, Young WS (Jan 2008). "Vasopressin: behavioral roles of an "original" neuropeptide". Progress in Neurobiology. 84 (1): 1–24. doi:10.1016/j.pneurobio.2007.10.007. PMC 2292122. PMID 18053631.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166148 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020123 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid18053631-5] Caldwell HK, Lee HJ, Macbeth AH, Young WS (Jan 2008). "Vasopressin: behavioral roles of an "original" neuropeptide". Progress in Neurobiology. 84 (1): 1–24. doi:10.1016/j.pneurobio.2007.10.007. PMC 2292122. PMID 18053631.

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