Venombin A (EC 3.4.21.74 , alpha-fibrinogenase , habutobin , zinc metalloproteinase Cbfib1.1 , zinc metalloproteinase Cbfib1.2 , zinc metalloproteinase Cbfib2 , ancrod enzyme .[ 1] [ 2] [ 3] [ 4] [ 5] catalyses the following chemical reaction
Selective cleavage of Arg- bond in fibrinogen , to form fibrin , and release fibrinopeptide A . The specificity of further degradation of fibrinogen varies with species origin of the enzyme This enzyme is a thrombin -like enzyme from venoms of snakes of the viper /rattlesnake group.
Examples include ancrod and batroxobin , two serine proteases from snakes that have been used in medical preparations.[citation needed
^ Nolan C, Hall LS, Barlow GH (1976). "Ancrod, the coagulating enzyme from Malayan pit viper (Agkistrodon rhodostoma) venom". Part B: Proteolytic Enzymes . Methods in Enzymology. Vol. 45. pp. 205–13. doi :10.1016/s0076-6879(76)45020-6 . ISBN 978-0-12-181945-3 PMID 1011992 . ^ Stocker K, Barlow GH (1976). "The coagulant enzyme from Bothrops atrox venom (Batroxobin)". Part B: Proteolytic Enzymes . Methods in Enzymology. Vol. 45. pp. 214–23. doi :10.1016/s0076-6879(76)45021-8 . ISBN 978-0-12-181945-3 PMID 1011993 . ^ Markland FS, Kettner C, Schiffman S, Shaw E, Bajwa SS, Reddy KN, Kirakossian H, Patkos GB, Theodor I, Pirkle H (March 1982). "Kallikrein-like activity of crotalase, a snake venom enzyme that clots fibrinogen" . Proceedings of the National Academy of Sciences of the United States of America . 79 (6): 1688–92. Bibcode :1982PNAS...79.1688M . doi :10.1073/pnas.79.6.1688 PMC 346045 PMID 7043462 . ^ Simmons G, Bundalian M, Theodor I, Martinoli J, Pirkle H (November 1985). "Action of crotalase, an enzyme with thrombin-like and kallikrein-like specificities, on tripeptide nitroanilide derivatives". Thrombosis Research . 40 (4): 555–61. doi :10.1016/0049-3848(85)90292-0 . PMID 2934864 . ^ Itoh N, Tanaka N, Funakoshi I, Kawasaki T, Mihashi S, Yamashina I (June 1988). "Organization of the gene for batroxobin, a thrombin-like snake venom enzyme. Homology with the trypsin/kallikrein gene family" . The Journal of Biological Chemistry . 263 (16): 7628–31. doi :10.1016/S0021-9258(18)68544-8 PMID 3163691 .