The vestibular lamina is responsible for the formation of the vestibule (the space bordered by the junction of the gingiva and the tissue of the inner cheek) and arises from a group of cells called the primary epithelial band. This band is created at about 37 days of development in utero.[1] The vestibular lamina forms shortly after the dental lamina and is positioned right in front of it. The vestibule is formed by the proliferation of the vestibular lamina into the ectomesenchyme.[1] The vestibular lamina is usually contrasted with the dental lamina, which develops concurrently and is involved with developing teeth. Both the vestibular lamina and the dental lamina arise from a group of epithelial cells, called the primary epithelial band.[1]
The vestibular lamina develops at 6th week of the intrauterine life as a result of proliferation of the primitive ectoderm that lines the primitive oral cavity.[2] The cells enlarge and then degenerate to form a cleft that separates the lips and cheeks at one side from the developing jaws and teeth at the other side. This cleft is the oral vestibule.
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