Vetus Latina manuscripts are handwritten copies of the earliest Latin translations of the Bible (including the Hebrew Bible/Old Testament, the Deuterocanonical books, and the New Testament), known as the "Vetus Latina" or "Old Latin". They originated prior to Jerome from multiple translators, and differ from Vulgate manuscripts which follow the late-4th-century Latin translation mainly done by Jerome.
Vetus Latina and Vulgate manuscripts continued to be copied alongside each other until the Late Middle Ages; many copies of the Bible or parts of it have been found using a mixture of Vetus Latina and Vulgate readings.