Vimentin

VIM
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesVIM, CTRCT30, HEL113, vimentin
External IDsOMIM: 193060; MGI: 98932; HomoloGene: 2538; GeneCards: VIM; OMA:VIM - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003380

NM_011701

RefSeq (protein)

NP_003371

NP_035831

Location (UCSC)Chr 10: 17.23 – 17.24 MbChr 2: 13.58 – 13.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Immunofluorescence staining pattern of vimentin antibodies. Produced by incubating vimentin primary antibodies and FITC labelled secondary antibodies with HEp-20-10 cells.

Vimentin is a structural protein that in humans is encoded by the VIM gene. Its name comes from the Latin vimentum which refers to an array of flexible rods.[5]

Immunofluorescence staining of HeLa Cells with antibody to reveal vimentin containing intermediate filaments in green and antibody to LAMP1 to reveal lysosomes in red. Nuclear DNA is seen in blue. Antibodies and image courtesy EnCor Biotechnology Inc.

Vimentin is a type III intermediate filament (IF) protein that is expressed in mesenchymal cells. IF proteins are found in all animal cells[6] as well as bacteria.[7] Intermediate filaments, along with tubulin-based microtubules and actin-based microfilaments, comprises the cytoskeleton. All IF proteins are expressed in a highly developmentally-regulated fashion; vimentin is the major cytoskeletal component of mesenchymal cells. Because of this, vimentin is often used as a marker of mesenchymally-derived cells or cells undergoing an epithelial-to-mesenchymal transition (EMT) during both normal development and metastatic progression.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000026025Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026728Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Franke WW, Schmid E, Osborn M, Weber K (October 1978). "Different intermediate-sized filaments distinguished by immunofluorescence microscopy". Proceedings of the National Academy of Sciences of the United States of America. 75 (10): 5034–5038. Bibcode:1978PNAS...75.5034F. doi:10.1073/pnas.75.10.5034. PMC 336257. PMID 368806.
  6. ^ Eriksson JE, Dechat T, Grin B, Helfand B, Mendez M, Pallari HM, et al. (July 2009). "Introducing intermediate filaments: from discovery to disease". The Journal of Clinical Investigation. 119 (7): 1763–1771. doi:10.1172/JCI38339. PMC 2701876. PMID 19587451.
  7. ^ Cabeen MT, Jacobs-Wagner C (2010). "The bacterial cytoskeleton". Annual Review of Genetics. 44: 365–392. doi:10.1146/annurev-genet-102108-134845. PMID 21047262.