Vinculin

VCL
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesVCL, CMD1W, CMH15, HEL114, MV, Mvinculin
External IDsOMIM: 193065; MGI: 98927; HomoloGene: 7594; GeneCards: VCL; OMA:VCL - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003373
NM_014000

NM_009502

RefSeq (protein)

NP_003364
NP_054706

NP_033528

Location (UCSC)Chr 10: 74 – 74.12 MbChr 14: 20.98 – 21.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Vinculin is a globular protein approximately 115 x 85 x 65 angstroms in linear dimension.

In mammalian cells, vinculin is a membrane-cytoskeletal protein in focal adhesion plaques that is involved in linkage of integrin adhesion molecules to the actin cytoskeleton. Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane.

Discovered independently by Benny Geiger[5] and Keith Burridge,[6] its sequence is 20%–30% similar to α-catenin, which serves a similar function.

Binding alternately to talin or α-actinin, vinculin's shape and, as a consequence, its binding properties are changed. The vinculin gene occurs as a single copy and what appears to be no close relative to take over functions in its absence. Its splice variant metavinculin (see below) also needs vinculin to heterodimerize and work in a dependent fashion.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000035403Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021823Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Geiger B (September 1979). "A 130K protein from chicken gizzard: its localization at the termini of microfilament bundles in cultured chicken cells". Cell. 18 (1): 193–205. doi:10.1016/0092-8674(79)90368-4. PMID 574428. S2CID 33153559.
  6. ^ Burridge K, Feramisco JR (March 1980). "Microinjection and localization of a 130K protein in living fibroblasts: a relationship to actin and fibronectin". Cell. 19 (3): 587–95. doi:10.1016/s0092-8674(80)80035-3. PMID 6988083. S2CID 43087259.