Virtual karyotype

Virtual karyotype is the digital information reflecting a karyotype, resulting from the analysis of short sequences of DNA from specific loci all over the genome, which are isolated and enumerated.[1] It detects genomic copy number variations at a higher resolution for level than conventional karyotyping or chromosome-based comparative genomic hybridization (CGH).[2] The main methods used for creating virtual karyotypes are array-comparative genomic hybridization and SNP arrays.

  1. ^ Digital karyotyping – Wang et al., 10.1073/pnas.202610899 – Proceedings of the National Academy of Sciences
  2. ^ Shinawi M, Cheung SW (2008). "The array CGH and its clinical applications". Drug Discov Today. 13 (17–18): 760–70. doi:10.1016/j.drudis.2008.06.007. PMID 18617013.