Vitamin D-binding protein

GC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1J78, 1J7E, 1KW2, 1KXP, 1LOT, 1MA9
Identifiers
Aliases	GC, DBP, DBP/GRD3, HEL-S-51, VDBG, VDBP, Gc-MAF, GcMAF, vitamin D binding protein, DBP-maf, VDB, GC vitamin D binding protein
External IDs	OMIM: 139200; MGI: 95669; HomoloGene: 486; GeneCards: GC; OMA:GC - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	71,804,041 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	89,605,757 bp
RNA expression pattern
	Top expressed in
	liver; ; right lobe of liver; ; gallbladder; ; pancreatic ductal cell; ; beta cell; ; duodenum; ; body of pancreas; ; jejunal mucosa; ; testicle; ; gonad;
	Top expressed in
	left lobe of liver; ; gallbladder; ; islet of Langerhans; ; fetal liver hematopoietic progenitor cell; ; human fetus; ; right kidney; ; human kidney; ; sexually immature organism; ; morula; ; stomach;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	vitamin D binding; calcidiol binding; actin binding; vitamin transmembrane transporter activity;
Cellular component	blood microparticle; extracellular region; lysosomal lumen; extracellular exosome; extracellular space; cytosol;
Biological process	vitamin D metabolic process; vitamin transport; transport; vitamin transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	2638
	14473
	ENSG00000145321
	ENSMUSG00000035540
	P02774
	P21614
	NM_000583; NM_001204306; NM_001204307
	NM_008096
	NP_000574; NP_001191235; NP_001191236
	NP_032122
	Wikidata
View/Edit Human	View/Edit Mouse

Vitamin D-binding protein (DBP), also/originally known as gc-globulin (group-specific component), is a protein that in humans is encoded by the GC gene.^[5]^[6] DBP is genetically the oldest member of the albuminoid family and appeared early in the evolution of vertebrates.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145321 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035540 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mikkelsen M, Jacobsen P, Henningsen K (Jul 1977). "Possible localization of Gc-System on chromosome 4. Loss of long arm 4 material associated with father-child incompatibility within the Gc-System". Human Heredity. 27 (2): 105–7. doi:10.1159/000152857. PMID 558959.
^ "Entrez Gene: GC group-specific component (vitamin D binding protein)".
^ Bouillon, R.; Schuit, F.; Antonio, L.; Rastinejad, F. (2020). "Vitamin D Binding Protein: A Historic Overview". Frontiers in Endocrinology. 10: 910. doi:10.3389/fendo.2019.00910. PMC 6965021. PMID 31998239.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000145321 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035540 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid558959-5] Mikkelsen M, Jacobsen P, Henningsen K (Jul 1977). "Possible localization of Gc-System on chromosome 4. Loss of long arm 4 material associated with father-child incompatibility within the Gc-System". Human Heredity. 27 (2): 105–7. doi:10.1159/000152857. PMID 558959.

[entrez-6] "Entrez Gene: GC group-specific component (vitamin D binding protein)".

[7] Bouillon, R.; Schuit, F.; Antonio, L.; Rastinejad, F. (2020). "Vitamin D Binding Protein: A Historic Overview". Frontiers in Endocrinology. 10: 910. doi:10.3389/fendo.2019.00910. PMC 6965021. PMID 31998239.

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