WNK1

WNK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4PWN
Identifiers
Aliases	WNK1, HSAN2, HSN2, KDP, PPP1R167, PRKPSK, p65, WNK lysine deficient protein kinase 1
External IDs	OMIM: 605232; MGI: 2442092; HomoloGene: 14253; GeneCards: WNK1; OMA:WNK1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.33 Start 752,579 bp[1] End 911,452 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 F1 Start 119,923,969 bp[2] End 120,038,672 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in internal globus pallidus inferior ganglion of vagus nerve subthalamic nucleus dorsal motor nucleus of vagus nerve external globus pallidus optic nerve pars reticulata trabecular bone pars compacta inferior olivary nucleus Top expressed in endothelial cell of lymphatic vessel stroma of bone marrow gastrula right lung lobe vestibular membrane of cochlear duct saccule primary oocyte myocardium of ventricle ciliary body cardiac muscle tissue of left ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein serine/threonine kinase inhibitor activity transferase activity nucleotide binding potassium channel inhibitor activity phosphatase binding protein kinase inhibitor activity kinase activity protein binding chloride channel inhibitor activity magnesium ion binding protein serine/threonine kinase activity ATP binding protein kinase activity protein kinase binding protein kinase activator activity Cellular component cytoplasm cytosol membrane Biological process phosphorylation negative regulation of phosphatase activity neuron development positive regulation of systemic arterial blood pressure protein autophosphorylation negative regulation of protein serine/threonine kinase activity peptidyl-threonine phosphorylation negative regulation of pancreatic juice secretion negative regulation of kinase activity regulation of cellular process ion transport intracellular signal transduction negative regulation of protein kinase activity regulation of sodium ion transport protein phosphorylation negative regulation of sodium ion transport activation of protein kinase activity cellular response to calcium ion positive regulation of canonical Wnt signaling pathway positive regulation of T cell chemotaxis peptidyl-serine phosphorylation positive regulation of ion transmembrane transporter activity negative regulation of cell-cell adhesion mediated by integrin negative regulation of heterotypic cell-cell adhesion negative regulation of GTPase activity chemokine (C-C motif) ligand 21 signaling pathway ion homeostasis T cell receptor signaling pathway lymphocyte migration into lymph node negative regulation of leukocyte cell-cell adhesion positive regulation of potassium ion import across plasma membrane cellular response to chemokine positive regulation of sodium ion transmembrane transporter activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 65125 232341 Ensembl ENSG00000060237 ENSMUSG00000045962 UniProt Q9H4A3 P83741 RefSeq (mRNA) NM_001184985 NM_014823 NM_018979 NM_213655 NM_001037155 NM_001185020 NM_001185021 NM_001199083 NM_001199084 NM_198703 RefSeq (protein) NP_001171914 NP_055638 NP_061852 NP_998820 NP_001171949 NP_001171950 NP_001186012 NP_001186013 NP_941992 Location (UCSC) Chr 12: 0.75 – 0.91 Mb Chr 6: 119.92 – 120.04 Mb PubMed search [3] [4]
Wikidata
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WNK (lysine deficient protein kinase 1), also known as WNK1, is an enzyme that is encoded by the WNK1 gene.^{[5][6][7][8][9]} WNK1 is serine-threonine protein kinase and part of the "with no lysine/K" kinase WNK family.^[5][6][7][9] The predominant role of WNK1 is the regulation of cation-Cl⁻ cotransporters (CCCs) such as the sodium chloride cotransporter (NCC), basolateral Na-K-Cl symporter (NKCC1), and potassium chloride cotransporter (KCC1) located within the kidney.^[5][6][9] CCCs mediate ion homeostasis and modulate blood pressure by transporting ions in and out of the cell.^[5] WNK1 mutations as a result have been implicated in blood pressure disorders/diseases; a prime example being familial hyperkalemic hypertension (FHHt).^{[5][6][7][8][9]}