WWOX

WWOX
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WMV
Identifiers
Aliases	WWOX, D16S432E, FOR, FRA16D, HHCMA56, PRO0128, SCAR12, SDR41C1, WOX1, EIEE28, WW domain containing oxidoreductase, DEE28
External IDs	OMIM: 605131; MGI: 1931237; HomoloGene: 56334; GeneCards: WWOX; OMA:WWOX - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	79,212,667 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	116,079,447 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; optic nerve; ; glomerulus; ; sural nerve; ; metanephric glomerulus; ; Epithelium of choroid plexus; ; pars reticulata; ; endothelial cell; ; kidney tubule; ; pars compacta;
	Top expressed in
	interventricular septum; ; neural layer of retina; ; zygote; ; amygdala; ; visual cortex; ; cerebellar cortex; ; secondary oocyte; ; primary visual cortex; ; spermatocyte; ; lens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transcription coactivator activity; protein dimerization activity; protein binding; enzyme binding; oxidoreductase activity;
Cellular component	cytoplasm; cytosol; Golgi apparatus; plasma membrane; microvillus; RNA polymerase II transcription regulator complex; mitochondrion; nucleus;
Biological process	cellular response to transforming growth factor beta stimulus; steroid metabolic process; extrinsic apoptotic signaling pathway; negative regulation of Wnt signaling pathway; skeletal system morphogenesis; Wnt signaling pathway; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; osteoblast differentiation; intrinsic apoptotic signaling pathway by p53 class mediator; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of transcription by RNA polymerase II; apoptotic process; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	51741
	80707
	ENSG00000186153
	ENSMUSG00000004637
	Q9NZC7
	Q91WL8
NM_001291997; NM_016373; NM_018560; NM_130788; NM_130790;
	NM_130791; NM_130792; NM_130844
	NM_019573
	NP_001278926; NP_057457; NP_570607
	NP_062519
	Wikidata
View/Edit Human	View/Edit Mouse

WW domain-containing oxidoreductase is an enzyme that in humans is encoded by the WWOX gene.^[5]^[6]^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186153 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004637 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bednarek AK, Laflin KJ, Daniel RL, Liao Q, Hawkins KA, Aldaz CM (May 2000). "WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer". Cancer Res. 60 (8): 2140–5. PMID 10786676.
^ Ried K, Finnis M, Hobson L, Mangelsdorf M, Dayan S, Nancarrow JK, Woollatt E, Kremmidiotis G, Gardner A, Venter D, Baker E, Richards RI (Sep 2000). "Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells". Hum Mol Genet. 9 (11): 1651–63. doi:10.1093/hmg/9.11.1651. PMID 10861292.
^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jörnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
^ "Entrez Gene: WWOX WW domain containing oxidoreductase".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000186153 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004637 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10786676-5] Bednarek AK, Laflin KJ, Daniel RL, Liao Q, Hawkins KA, Aldaz CM (May 2000). "WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer". Cancer Res. 60 (8): 2140–5. PMID 10786676.

[pmid10861292-6] Ried K, Finnis M, Hobson L, Mangelsdorf M, Dayan S, Nancarrow JK, Woollatt E, Kremmidiotis G, Gardner A, Venter D, Baker E, Richards RI (Sep 2000). "Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells". Hum Mol Genet. 9 (11): 1651–63. doi:10.1093/hmg/9.11.1651. PMID 10861292.

[pmid19027726-7] Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jörnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.

[entrez-8] "Entrez Gene: WWOX WW domain containing oxidoreductase".

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