Werner syndrome helicase

WRN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2AXL, 2DGZ, 2E1E, 2E1F, 2FBT, 2FBV, 2FBX, 2FBY, 2FC0, 3AAF
Identifiers
Aliases	WRN, RECQ3, RECQL2, RECQL3, Werner syndrome RecQ like helicase, WRN RecQ like helicase
External IDs	OMIM: 604611; MGI: 109635; HomoloGene: 6659; GeneCards: WRN; OMA:WRN - orthologs
EC number	3.1.-.-
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p12 Start 31,033,788 bp[1] End 31,176,138 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 A3|8 20.3 cM Start 33,724,412 bp[2] End 33,875,555 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon sperm testicle epithelium of colon gonad gastric mucosa secondary oocyte body of uterus sural nerve ventricular zone Top expressed in tail of embryo zygote spermatid secondary oocyte granulocyte fetal liver hematopoietic progenitor cell spermatocyte lumbar spinal ganglion cumulus cell genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding nucleotide binding manganese ion binding protein homodimerization activity helicase activity DNA helicase activity bubble DNA binding chromatin binding metal ion binding G-quadruplex DNA binding ATPase activity protein binding catalytic activity 3'-5' exonuclease activity Y-form DNA binding nucleic acid binding nuclease activity 3'-5' DNA helicase activity four-way junction helicase activity ATP binding magnesium ion binding hydrolase activity exonuclease activity telomeric D-loop binding 3'-flap-structured DNA binding four-way junction DNA binding forked DNA-dependent helicase activity telomeric G-quadruplex DNA binding 8-hydroxy-2'-deoxyguanosine DNA binding protein-containing complex binding MutLalpha complex binding Cellular component centrosome intracellular anatomical structure nucleoplasm nucleolus neuron projection MutLalpha complex nucleus cytoplasm nuclear speck telomere replication fork DNA replication factor A complex chromosome site of double-strand break Biological process regulation of apoptotic process positive regulation of hydrolase activity DNA recombination cellular response to starvation DNA metabolic process human ageing response to oxidative stress cellular response to DNA damage stimulus regulation of growth rate brain development cell metabolism cellular response to gamma radiation replication fork processing multicellular organism aging metabolism nucleobase-containing compound metabolic process response to UV-C base-excision repair double-strand break repair DNA repair nucleic acid phosphodiester bond hydrolysis double-strand break repair via homologous recombination DNA duplex unwinding DNA replication telomeric D-loop disassembly t-circle formation positive regulation of strand invasion telomere maintenance G-quadruplex DNA unwinding protein localization to nucleolus DNA synthesis involved in DNA repair determination of adult lifespan regulation of signal transduction by p53 class mediator DNA unwinding involved in DNA replication Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7486 22427 Ensembl ENSG00000165392 ENSMUSG00000031583 UniProt Q14191 O09053 RefSeq (mRNA) NM_000553 NM_001122822 NM_011721 RefSeq (protein) NP_000544 NP_001116294 NP_035851 Location (UCSC) Chr 8: 31.03 – 31.18 Mb Chr 8: 33.72 – 33.88 Mb PubMed search [3] [4]
Wikidata
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Werner syndrome ATP-dependent helicase, also known as DNA helicase, RecQ-like type 3, is an enzyme that in humans is encoded by the WRN gene. WRN is a member of the RecQ Helicase family.^[5] Helicase enzymes generally unwind and separate double-stranded DNA. These activities are necessary before DNA can be copied in preparation for cell division (DNA replication). Helicase enzymes are also critical for making a blueprint of a gene for protein production, a process called transcription. Further evidence suggests that Werner protein plays a critical role in repairing DNA. Overall, this protein helps maintain the structure and integrity of a person's DNA.

The WRN gene is located on the short (p) arm of chromosome 8 between positions 12 and 11.2, from base pair 31,010,319 to base pair 31,150,818.