Westerner may refer to:
- a person from the Western world
- a person from the Western United States
- Westerner (Missouri Pacific train), a train operated by the Missouri Pacific Railroad between St. Louis and Kansas City, Missouri
- Westerner (Nickel Plate train), a train operated by the New York, Chicago and St. Louis Railroad between Buffalo and Chicago
- Westerner (Texas & Pacific train), a train operated by the Texas and Pacific Railway between St. Louis and El Paso
- USS Westerner (ID-2890), a United States Navy cargo ship in commission from 1918 to 1919
- Westerner, a limited-edition, luxury version of the AMC Rebel station wagon
- Westerner (horse) (born 1999), 2005 winner of the Ascot Gold Cup horse race
- Westerner Gambling House and Saloon, a former Las Vegas casino owned by Benny Binion
- Westerner, a short-lived comic book (three issues) put out by I. W. Publications
- Westerners (Korean political faction), a political faction in 16th-century Korea