Wharton's jelly (substantia gelatinea funiculi umbilicalis) is a gelatinous substance within the umbilical cord,[1] largely made up of mucopolysaccharides (hyaluronic acid and chondroitin sulfate). It acts as a mucous connective tissue containing some fibroblasts and macrophages, and is derived from extra-embryonic mesoderm of the connecting stalk.