Who Cares or Who Cares? may refer to:
- "Who Cares?" (George and Ira Gershwin song) (1931)
- "Who Cares?" (Gnarls Barkley song) (2006)
- "Who Cares" (Paul McCartney song) (2018)
- Who Cares? (ballet), a 1970 ballet by George Balanchine made to songs by George Gershwin
- Who Cares? (1919 film), a silent comedy film starring Constance Talmadge
- Who Cares (1925 film), a silent film starring Dorothy Devore
- Who Cares? (band), the ensemble responsible for performing 1985 charity single "Doctor in Distress"
- Who Cares? (album), a 2022 album by Rex Orange County
- WhoCares, a musical charity project by Ian Gillan, Tony Iommi & Friends
- Ian Gillan & Tony Iommi: WhoCares, an album by WhoCares
- Who Cares, the debut album of Australian rock band the Poor
- "Who Cares", a Don Gibson song (1959)
- "Who Cares?", a song by Huey Lewis and the News from the album, Huey Lewis and the News (1980)