Wicker is a surname. Notable people by that name include:
- Allan Wicker (born 1941), psychologist.
- Bob Wicker (1878–1955), American baseball player.
- Cassius Milton Wicker (1846–1913), railroad manager and banker.
- Dennis A. Wicker (born 1952), American lawyer and politician.
- Floyd Wicker (born 1943), American former professional baseball outfielder.
- George R. Wicker (1877–1935), American agricultural businessman.
- Ireene Wicker (1905–1987), American singer and actress.
- John J. Wicker, Jr. (1893–1985), American lawyer and Democratic politician.
- Kemp Wicker (1906–1973), American pitcher in Major League Baseball.
- Louis Wicker (born 1959), American atmospheric scientist.
- Nancy L. Wicker, professor of art history at the University of Mississippi.
- Randy Wicker (born 1938), American author, activist and blogger.
- Roger Wicker (born 1951), U.S. Senator for Mississippi.
- Tom Wicker (1926–2011), American journalist.
- Veronica DiCarlo Wicker (1930–1994), United States federal judge.