William Drayton may refer to:
- William Drayton Sr. (1732–1790), American judge from Charleston, South Carolina
- William Drayton (1776–1846), U.S. Congressman from Charleston, South Carolina
- Bill Drayton (born 1943), American social entrepreneur and environmentalist
- Flavor Flav (born 1959), real name William Drayton, American rapper with Public Enemy
- William Henry Drayton (1742–1779), American lawyer, South Carolina delegate to Continental Congress
- Billy Drayton, character in The Mist