William Grayson (disambiguation)

• William Grayson (1740–1790) was a U.S. Senator from Virginia.

William Grayson may also refer to:

• William Grayson Carter (died 1849), American politician from Kentucky and grandson of the senator
• William J. Grayson (1788–1863), U.S. Representative from South Carolina
• William W. Grayson (1876-1941), American soldier, known for firing the shot that started the Philippine–American War
• SS William Grayson, a Liberty ship, named for the senator