William Grimes

William Grimes may refer to:

• William Alvan Grimes (1911–1999), Chief Justice of the New Hampshire Supreme Court
• William C. Grimes (1857–1931), American politician and businessman
• William Grimes (journalist) (born 1959), former restaurant critic and current obituary writer for The New York Times
• W. F. Grimes (1905–1988), Welsh archaeologist
• William Grimes (footballer) (1886–?), English professional footballer for Bradford City and Derby County
• William Grimes (ex-slave) (1784–1865), author of what is considered the first narrative of an American ex-slave, Life of William Grimes, the Runaway Slave
• William P. Grimes (1868–1939), American politician in Wisconsin