William Humphreys

William Humphreys may refer to:

• William Y. Humphreys (1890–1933), U.S. Congressman from Mississippi
• William Jackson Humphreys (1862–1949), American physicist and meteorologist
• William Humphreys Jackson (1839–1915), U.S. Congressman from Maryland
• William Humfrey (died 1579), also written William Humphreys, Elizabethan goldsmith
• William Benbow Humphreys (1889–1965), South African politician
• William Humphreys (footballer), English footballer
• Billy Humphreys (1884–?), English footballer