William Irvine may refer to:
- William Irvine (soldier) (c. 1298–?), Clerk of the Rolls for Scotland
- William Irvine (general) (1741–1804), American Revolutionary War general, congressman from Pennsylvania
- Col. William Irvine (18th century), American Revolutionary soldier and pioneer, namesake of Irvine, Kentucky
- William Irvine (lawyer) (1820–1882), American Civil War soldier, congressman from New York
- William Irvine (historian) (1840–1911), British administrator of the Indian Civil Service, known for works on the Moghul Empire
- William Irvine (Australian politician) (1858–1943), Premier of Victoria
- William Irvine (Scottish evangelist) (1863–1947), evangelist considered the founder of various nameless sects
- William Irvine (Canadian politician) (1885–1962), Canadian politician
- William Irvine (rugby union) (1898–1952), New Zealand rugby union player
- William C. Irvine (missionary) (1871–1946), editor of the Indian Christian and author of Modern Heresies Exposed (1917)
- William Irvine (Rhodesian politician) (fl. 1980s)
- William D. Irvine (1944-2021), Canadian historian
- Willie Irvine (born 1943), footballer from Northern Ireland, played for Burnley, Preston, Brighton & Hove Albion and Northern Ireland
- Willie Irvine (footballer, born 1956), Scottish footballer, played for Alloa, Motherwell and Hibernian
- Willie Irvine (footballer, born 1963), Scottish footballer, played for Hibernian, Airdrie, Dunfermline, Alloa and Stenhousemuir
- William S. Irvine (1851–1942), member of the Wisconsin Legislature
- William Irvine (bishop) (fl. 1718), Scottish bishop
- William Irvine (chemist) (1743–1787), British doctor and chemist
- William Irvine (1776–1811), Scottish physician
- William Mann Irvine (1865–1928), American academic
- William C. Irvine (politician) (1852–1924), American politician in Wyoming
- Bill Irvine (1926–2008), ballroom dancer