William Reed may refer to:
- William Reed (athlete) (born 1970), American sprinter
- William Reed (author) (1830–1920), author of The Phantom of the Poles (1906)
- William Reed (British colonial official) (c. 1670–1728), Acting Governor of North-Carolina (1722–1724)
- William Reed (composer) (1910–2002), English composer
- William Reed (musician) (1859–1945), Canadian organist, conductor, and composer
- William Reed (politician) (1776–1837), United States Representative from Massachusetts
- William Reed (publisher) (1830–1920), English trade magazine publisher; founder of William Reed Ltd
- William Reed (RAF officer) (1896–?), British World War I flying ace
- William Reed (sprinter, born 2005) (born 2005), Marshallese sprinter
- William B. Reed (politician) (1833–1909), mayor of South Norwalk (1891–1893), oyster grower and shipper
- William Bradford Reed (1806–1876), American politician and journalist
- William Henry Reed (1876–1942), violinist and author of Elgar as I Knew Him
- William L. Reed (politician) (1866-?), member of the Massachusetts House of Representatives
- William Maxwell Reed (1871–1962), American writer of science books for children
- William Norman Reed (1917–1944), American fighter ace, Flying Tiger and United States Army Air Corps lieutenant colonel
- William R. Reed (c. 1915–1971), college athletics administrator in the United States
- William Samuel Reed (1864–1941), Progressive party member of the Canadian House of Commons
- William W. Reed (1825–1916), Wisconsin State Senator and Assemblyman
- Bill Reed (born 1954), retired professional ice hockey defenceman
- Billy Reed (footballer) (1928–2003), Welsh international footballer
- Billy Reed (baseball) (1922–2005), baseball player