William Sandys, 1st Baron Sandys (1470 – 4 December 1540), KG, of The Vyne in the parish of Sherborne St John, Hampshire, was an English diplomat, and a favourite of King Henry VIII, whom he served as Lord Chamberlain. In the 1520s he built a palatial Tudor-style mansion at "The Vyne", which survives in a reduced and classicised form as a possession of the National Trust.