William Weber may refer to:
- William Alfred Weber (1918–2020), American botanist
- William Gilmore Weber (born 1963), American guitarist, former member of rock band The Murder Junkies
- William V. Weber (1901–1989), Michigan State Representative
- Ben Weber (composer) (William Jennings Bryan Weber, 1916–1979), American composer
- Bill Weber (Minnesota politician) (born 1956), Minnesota State Senator
- Bill Weber (New York politician), New York State Senator
- Bill Weber (born 1957), former NBC and TNT sports commentator
- Wilhelm Eduard Weber (1804–1891), German physicist