Wriothesley (pronounced [1] RY-əthss-lee) may refer to:
- William Wriothesley (died 1513), officer of arms at the College of Arms in London
- Thomas Wriothesley (died 1534), long-serving officer of arms at the College of Arms in London
- Thomas Wriothesley, 1st Earl of Southampton KG (1505–1550), English politician of the Tudor period
- Charles Wriothesley (1508–1562), long-serving officer of arms at the College of Arms in London
- Henry Wriothesley, 2nd Earl of Southampton (1545–1581), English noble
- Mary Wriothesley, Countess of Southampton (1552–1607), English countess
- Elizabeth Wriothesley, Countess of Southampton (1572–1655), chief lady-in-waiting to Elizabeth I of England
- Henry Wriothesley, 3rd Earl of Southampton (1573–1624), English noble
- Thomas Wriothesley, 4th Earl of Southampton KG (1607–1667), 17th-century English statesman, and supporter of Charles II
- Rachel Wriothesley, Lady Russell (1636–1723), English noblewoman, heiress, and author
- Baptist Wriothesley Noel (1799–1873), English evangelical clergyman of aristocratic family
- Wriothesley, a fictional character in Genshin Impact.
- ^ Wells, J. C. Longman Pronunciation Dictionary. 3rd edition. Harlow: Pearson Education Limited, 2008.