X22 or X-22 may refer to:
- Bell X-22, an American experimental tilt-fan aircraft of the 1960s
- Kh-22 (Russian: X-22; AS-4 'Kitchen'), an anti-ship missile developed by the Soviet Union
- Paul Magriel (born 1946; nicknamed "X-22"), American professional backgammon and poker player
- \x22, the quotation mark (Unicode codepoint hex &x22;)