XYLT1

XYLT1
Identifiers
Aliases	XYLT1, DBQD2, PXT-I, XT1, XTI, XYLTI, xylT-I, xylosyltransferase 1
External IDs	OMIM: 608124; MGI: 2451073; HomoloGene: 32534; GeneCards: XYLT1; OMA:XYLT1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	17,470,960 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	117,272,803 bp
RNA expression pattern
	Top expressed in
	tibia; ; cartilage tissue; ; hair follicle; ; Region I of hippocampus proper; ; Epithelium of choroid plexus; ; synovial joint; ; gingival epithelium; ; retinal pigment epithelium; ; entorhinal cortex; ; Brodmann area 23;
	Top expressed in
	subiculum; ; anterior amygdaloid area; ; primary motor cortex; ; deep cerebellar nuclei; ; retinal pigment epithelium; ; ventromedial nucleus; ; cingulate gyrus; ; paraventricular nucleus of hypothalamus; ; granulocyte; ; mammillary body;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein xylosyltransferase activity; transferase activity; acetylglucosaminyltransferase activity; glycosyltransferase activity; metal ion binding;
Cellular component	integral component of membrane; extracellular region; Golgi apparatus; endoplasmic reticulum membrane; endoplasmic reticulum; membrane; Golgi membrane; Golgi cis cisterna; extracellular space;
Biological process	chondroitin sulfate biosynthetic process; heparan sulfate proteoglycan biosynthetic process; glycosaminoglycan biosynthetic process; glycosaminoglycan metabolic process; proteoglycan biosynthetic process; ossification involved in bone maturation; embryonic skeletal system development; chondroitin sulfate proteoglycan biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	64131
	233781
	ENSG00000103489; ENSG00000285395
	ENSMUSG00000030657
	Q86Y38
	Q811B1
	NM_022166
	NM_175645
	NP_071449
	NP_783576
	Wikidata
View/Edit Human	View/Edit Mouse

Xylosyltransferase 1 is an enzyme that in humans is encoded by the XYLT1 gene.^[5]^[6]

Xylosyltransferase (XT; EC 2.4.2.26) catalyzes the transfer of UDP-xylose to serine residues within XT recognition sequences of target proteins. Addition of this xylose to the core protein is required for the biosynthesis of the glycosaminoglycan chains characteristic of proteoglycans.[supplied by OMIM]^[6]

^ ^a ^b ^c ENSG00000285395 GRCh38: Ensembl release 89: ENSG00000103489, ENSG00000285395 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030657 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Götting C, Kuhn J, Zahn R, Brinkmann T, Kleesiek K (December 2000). "Molecular cloning and expression of human UDP-d-Xylose:proteoglycan core protein beta-d-xylosyltransferase and its first isoform XT-II". Journal of Molecular Biology. 304 (4): 517–528. doi:10.1006/jmbi.2000.4261. PMID 11099377.
^ ^a ^b "Entrez Gene: XYLT1 xylosyltransferase I".

[refGRCh38Ensembl-1] ENSG00000285395 GRCh38: Ensembl release 89: ENSG00000103489, ENSG00000285395 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030657 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11099377-5] Götting C, Kuhn J, Zahn R, Brinkmann T, Kleesiek K (December 2000). "Molecular cloning and expression of human UDP-d-Xylose:proteoglycan core protein beta-d-xylosyltransferase and its first isoform XT-II". Journal of Molecular Biology. 304 (4): 517–528. doi:10.1006/jmbi.2000.4261. PMID 11099377.

[entrez-6] "Entrez Gene: XYLT1 xylosyltransferase I".

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