Xiaojiang Chen

Xiaojiang S. Chen
Born1963 (age 60–61)
Hunan, China
Known forVirology, Immunology, Molecular Biology and Structural Biology
Academic background
EducationBS in Biology
PhD in Biochemistry and Molecular Biology, Virology
Alma materShihezi University, China
University of California, USA
Academic work
InstitutionsUniversity of Southern California (USC), USA
University of Colorado, USA
Harvard University, USA

Xiaojiang S. Chen (Chinese: 陈小江; born in 1963) is a Chinese-American virologist, immunologist, and structural biologist. He is a professor of Biological Sciences and Chemistry and Director of the Center of Excellence in Nano Biophysics/Structural Biology at the University of Southern California.[1]

Chen is most known for his work on structural molecular virology and cancer biology.[2] He has made distinct discoveries in the fields of viral replication,[3] tumor suppression,[4][5] cell proliferation,[6] and DNA transaction (replication, mutation and repair).[7][8][9]

Chen is a Fellow of the American Association for the Advancement of Science (AAAS).[10]

  1. ^ "Faculty Profile > USC Dana and David Dornsife College of Letters, Arts and Sciences". dornsife.usc.edu.
  2. ^ "Xiaojiang S. Chen | University of Southern California | 111 Publications | 6639 Citations | Related Authors". SciSpace - Author.
  3. ^ Ito, Fumiaki; Alvarez-Cabrera, Ana L.; Liu, Shiheng; Yang, Hanjing; Shiriaeva, Anna; Zhou, Z. Hong; Chen, Xiaojiang S. (January 4, 2023). "Structural basis for HIV-1 antagonism of host APOBEC3G via Cullin E3 ligase". Science Advances. 9 (1): eade3168. Bibcode:2023SciA....9E3168I. doi:10.1126/sciadv.ade3168. PMC 9812381. PMID 36598981.
  4. ^ Lilyestrom, Wayne; Klein, Michael G.; Zhang, Rongguang; Joachimiak, Andrzej; Chen, Xiaojiang S. (September 1, 2006). "Crystal structure of SV40 large T-antigen bound to p53: interplay between a viral oncoprotein and a cellular tumor suppressor". Genes & Development. 20 (17): 2373–2382. doi:10.1101/gad.1456306. PMC 1560412. PMID 16951253.
  5. ^ Li, Dawei; Zhao, Rui; Lilyestrom, Wayne; Gai, Dahai; Zhang, Rongguang; DeCaprio, James A.; Fanning, Ellen; Jochimiak, Andrzej; Szakonyi, Gerda; Chen, Xiaojiang S. (May 10, 2003). "Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen". Nature. 423 (6939): 512–518. Bibcode:2003Natur.423..512L. doi:10.1038/nature01691. PMID 12774115. S2CID 4345600.
  6. ^ Yang, Hanjing; Kim, Kyumin; Li, Shuxing; Pacheco, Josue; Chen, Xiaojiang S. (December 5, 2022). "Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G". Nature Communications. 13 (1): 7498. Bibcode:2022NatCo..13.7498Y. doi:10.1038/s41467-022-35201-9. PMC 9722718. PMID 36470880.
  7. ^ Fu, Yang; Ito, Fumiaki; Zhang, Gewen; Fernandez, Braulio; Yang, Hanjing; Chen, Xiaojiang S. (October 1, 2015). "DNA cytosine and methylcytosine deamination by APOBEC3B: enhancing methylcytosine deamination by engineering APOBEC3B". The Biochemical Journal. 471 (1): 25–35. doi:10.1042/BJ20150382. PMC 4613526. PMID 26195824.
  8. ^ Gai, Dahai; Zhao, Rui; Li, Dawei; Finkielstein, Carla V.; Chen, Xiaojiang S. (October 1, 2004). "Mechanisms of conformational change for a replicative hexameric helicase of SV40 large tumor antigen". Cell. 119 (1): 47–60. doi:10.1016/j.cell.2004.09.017. PMID 15454080. S2CID 7110913.
  9. ^ G, Chandramouly; J, Zhao; S, McDevitt; T, Rusanov; T, Hoang; N, Borisonnik; T, Treddinick; Fw, Lopezcolorado; T, Kent; La, Siddique; J, Mallon; J, Huhn; Z, Shoda; E, Kashkina; A, Brambati; Jm, Stark; Xs, Chen; Rt, Pomerantz (June 11, 2021). "Polθ reverse transcribes RNA and promotes RNA-templated DNA repair". Science Advances. 7 (24). Bibcode:2021SciA....7.1771C. doi:10.1126/sciadv.abf1771. PMC 8195485. PMID 34117057. S2CID 235405361.
  10. ^ "2017 AAAS Fellows Recognized for Advancing Science | American Association for the Advancement of Science (AAAS)". www.aaas.org.