Zanamivir

Zanamivir
Clinical data
Pronunciation/zəˈnæmɪvɪər/
Trade namesRelenza
AHFS/Drugs.comMonograph
License data
Pregnancy
category
  • AU: B1
Routes of
administration
Inhalation, intravenous
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability2% (oral)
Protein binding<10%
MetabolismNegligible
Elimination half-life2.5–5.1 hours
ExcretionKidney
Identifiers
  • (2R,3R,4S)-4-guanidino-3-(prop-1-en-2-ylamino)-2-((1R,2R)-1,2,3-trihydroxypropyl)-3,4-dihydro-2H-pyran-6-carboxylic acid
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB ligand
CompTox Dashboard (EPA)
ECHA InfoCard100.218.632 Edit this at Wikidata
Chemical and physical data
FormulaC12H20N4O7
Molar mass332.313 g·mol−1
3D model (JSmol)
  • O=C(O)C=1O[C@@H]([C@H](O)[C@H](O)CO)[C@H](NC(=O)C)[C@@H](/N=C(\N)N)C=1
  • InChI=1S/C12H20N4O7/c1-4(18)15-8-5(16-12(13)14)2-7(11(21)22)23-10(8)9(20)6(19)3-17/h2,5-6,8-10,17,19-20H,3H2,1H3,(H,15,18)(H,21,22)(H4,13,14,16)/t5-,6+,8+,9+,10+/m0/s1 checkY
  • Key:ARAIBEBZBOPLMB-UFGQHTETSA-N checkY
  (verify)

Zanamivir is a medication used to treat and prevent influenza caused by influenza A and influenza B viruses. It is a neuraminidase inhibitor and was developed by the Australian biotech firm Biota Holdings. It was licensed to Glaxo in 1990 and approved in the US in 1999, only for use as a treatment for influenza. In 2006, it was approved for prevention of influenza A and B.[3] Zanamivir was the first neuraminidase inhibitor commercially developed. It is marketed by GlaxoSmithKline under the trade name Relenza as a powder for oral inhalation.

  1. ^ "Relenza- zanamivir powder". DailyMed. 19 October 2021. Retrieved 30 September 2022.
  2. ^ "List of nationally authorised medicinal products" (PDF). European Medicines Agency.
  3. ^ "FDA Approves a Second Drug for the Prevention of Influenza A and B in Adults and Children FDA press release March 29, 2006". FDA. Archived from the original on 6 March 2010. Retrieved 16 December 2019.