 Zhong Zhong and Hua Hua at nearly 2 months of age | |
| Species | Macaca fascicularis |
|---|---|
| Sex | Female |
| Born | Zhong Zhong 27 November 2017 (age 6 years) Hua Hua 5 December 2017 (age 6 years) Shanghai, China |
| Nation from | China |
| Known for | First primates to be cloned using the somatic cell nuclear transfer method |
Zhong Zhong (Chinese: 中中; pinyin: Zhōng Zhōng, born 27 November 2017) and Hua Hua (Chinese: 华华; pinyin: Huá Huá, born 5 December 2017) are a pair of identical crab-eating macaques (also referred to as cynomolgus monkeys) that were created through somatic cell nuclear transfer (SCNT), the same cloning technique that produced Dolly the sheep in 1996. They are the first cloned primates produced by this technique. Unlike previous attempts to clone monkeys, the donated nuclei came from fetal cells, not embryonic cells.[1][2][3][4][5] The primates were born from two independent surrogate pregnancies at the Institute of Neuroscience of the Chinese Academy of Sciences in Shanghai.[6]
- ^ Liu, Zhen; Cai, Yijun; Wang, Yan; Nie, Yanhong; Zhang, Chenchen; Xu, Yuting; Zhang, Xiaotong; Lu, Yong; Wang, Zhanyang; Poo, Muming; Sun, Qiang (24 January 2018). "Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer". Cell. 172 (4): 881–887.e7. doi:10.1016/j.cell.2018.01.020. PMID 29395327.
- ^ Scholarly sources:
- Normile, Dennis (24 January 2018). "These monkey twins are the first primate clones made by the method that developed Dolly". Science. doi:10.1126/science.aat1066. Retrieved 24 January 2018.
- Cyranoski, David (24 January 2018). "First monkeys cloned with technique that made Dolly the sheep – Chinese scientists create cloned primates that could revolutionize studies of human disease". Nature. 553 (7689): 387–388. Bibcode:2018Natur.553..387C. doi:10.1038/d41586-018-01027-z. PMID 29368720.
- ^ Maron, Dina Fine (24 January 2018). "First Primate Clones Produced Using the "Dolly" Method – The success with monkeys could ignite new ethical debates and medical research". Scientific American. Retrieved 24 January 2018.
- ^ Kolata, Gina (24 January 2018). "Yes, They've Cloned Monkeys in China. That Doesn't Mean You're Next". The New York Times. Retrieved 25 January 2018.
- ^ Popular sources:
- Briggs, Helen (24 January 2018). "First monkey clones created in Chinese laboratory". BBC News. Retrieved 24 January 2018.
- Hotz, Robert Lee (24 January 2018). "China Breaks a Cloning Barrier: Primates – The development heralds the possibility of genetically engineered primates for drug testing, gene editing and brain research". The Wall Street Journal. Retrieved 24 January 2018.
- ^ Staff (24 January 2018). "Meet Zhong Zhong and Hua Hua, the first monkey clones produced by method that made Dolly". Science Daily. Cell Press. Retrieved 25 January 2018.