Zinc finger FYVE domain-containing protein 9

ZFYVE9
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesZFYVE9, MADHIP, NSP, PPP1R173, SARA, SMADIP, zinc finger FYVE-type containing 9
External IDsOMIM: 603755; MGI: 2652838; HomoloGene: 3527; GeneCards: ZFYVE9; OMA:ZFYVE9 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004799
NM_007323
NM_007324

NM_183300
NM_001347163
NM_001384118

RefSeq (protein)

NP_004790
NP_015563

n/a

Location (UCSC)Chr 1: 52.14 – 52.35 MbChr 4: 108.49 – 108.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger FYVE domain-containing protein 9 or SARA (SMAD anchor for receptor activation) is a protein that in humans is encoded by the ZFYVE9 gene.[5] SARA contains a double zinc finger (FYVE domain).

SARA is an anchoring protein involved in TGF beta signaling. It binds to the MH2 domain of the R-SMADs SMAD2 and SMAD3 as well as the type I TGF beta receptors.[6] It facilitates the phosphorylation of the R-SMAD, which subsequently dissociates from SARA and the receptor and binds a coSMAD where they enter the nucleus as transcription factors.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000157077Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034557Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL (December 1998). "SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor". Cell. 95 (6): 779–791. doi:10.1016/S0092-8674(00)81701-8. PMID 9865696. S2CID 6194655.
  6. ^ Lin HK, Bergmann S, Pandolfi PP (September 2004). "Cytoplasmic PML function in TGF-beta signalling". Nature. 431 (7005): 205–211. Bibcode:2004Natur.431..205L. doi:10.1038/nature02783. PMID 15356634. S2CID 4301789.