Zona pellucida-like domain

Zona pellucida-like domain
Identifiers
SymbolZona_pellucida
PfamPF00100
InterProIPR001507
SMARTSM00241
PROSITEPDOC00577
Membranome146
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

The zona pellucida-like domain (ZP domain / ZP-like domain / ZP module)[1][2] is a large protein region of about 260 amino acids. It has been recognised in a variety of receptor-like eukaryotic glycoproteins.[1] All of these molecules are mosaic proteins with a large extracellular region composed of various domains, often followed by either a transmembrane region and a very short cytoplasmic region or by a GPI-anchor.[2]

Functional and crystallographic studies revealed that the "ZP domain" region common to all these proteins is a protein polymerization module that consists of two distinct but structurally related immunoglobulin-like domains, ZP-N and ZP-C.[3][4][5][6][7][8][9][10] The ZP module is located in the C-terminal portion of the extracellular region and – with the exception of non-polymeric family member ENG[11] – contains 8 or 10 conserved Cys residues involved in disulfide bonds.[5][6][9]

The first 3D structure of a ZP module protein filament, native human uromodulin (UMOD), was determined by cryo-EM.[12][13]

Additional copies of isolated ZP-N domains are found in the N-terminal region of egg coat protein subunits involved in fertilization in both vertebrates and invertebrates, such as human zona pellucida components ZP1, ZP2 and ZP4 and mollusk vitelline envelope receptor for egg lysin (VERL).[5][14][15]

  1. ^ a b Bork P, Sander C (1992). "A large domain common to sperm receptors (Zp2 and Zp3) and TGF-beta type III receptor". FEBS Lett. 300 (3): 237–40. doi:10.1016/0014-5793(92)80853-9. PMID 1313375. S2CID 38778076.
  2. ^ a b Jovine L, Darie CC, Litscher ES, Wassarman PM (2005). "Zona pellucida domain proteins". Annu. Rev. Biochem. 74: 83–114. doi:10.1146/annurev.biochem.74.082803.133039. PMID 15952882.
  3. ^ Jovine L, Qi H, Williams Z, Litscher E, Wassarman PM (2002). "The ZP domain is a conserved module for polymerization of extracellular proteins". Nat. Cell Biol. 4 (6): 457–61. doi:10.1038/ncb802. PMID 12021773. S2CID 11575790.
  4. ^ Jovine L, Qi H, Williams Z, Litscher ES, Wassarman PM (2004). "A duplicated motif controls assembly of zona pellucida domain proteins". Proc. Natl. Acad. Sci. U.S.A. 101 (16): 5922–7. Bibcode:2004PNAS..101.5922J. doi:10.1073/pnas.0401600101. PMC 395899. PMID 15079052.
  5. ^ a b c Monné M, Han L, Schwend T, Burendahl S, Jovine L (2008). "Crystal structure of the ZP-N domain of ZP3 reveals the core fold of animal egg coats". Nature. 456 (7222): 653–7. Bibcode:2008Natur.456..653M. doi:10.1038/nature07599. hdl:11563/8930. PMID 19052627. S2CID 4430083. PDB: 3D4C, 3D4G, 3EF7​
  6. ^ a b Han L, Monné M, Okumura, H, Schwend, T, Cherry, AL, Flot, D, Matsuda, T, Jovine, L (2010). "Insights into egg coat assembly and egg-sperm interaction from the X-ray structure of full-length ZP3". Cell. 143 (3): 404–15. doi:10.1016/j.cell.2010.09.041. hdl:11563/8931. PMID 20970175. S2CID 18583237. PDB: 3NK3, 3NK4​
  7. ^ Lin SJ, Hu Y, Zhu J, Woodruff TK, Jardetzky TS (2011). "Structure of betaglycan zona pellucida (ZP)-C domain provides insights into ZP-mediated protein polymerization and TGF-beta binding". Proc Natl Acad Sci U S A. 108 (13): 5232–6. Bibcode:2011PNAS..108.5232L. doi:10.1073/pnas.1010689108. PMC 3069177. PMID 21402931. PDB: 3QW9​
  8. ^ Diestel U, Resch M, Meinhardt K, Weiler S, Hellmann TV, Mueller TD, Nickel J, Eichler J, Muller YA (2013). "Identification of a Novel TGF-β-Binding Site in the Zona Pellucida C-terminal (ZP-C) Domain of TGF-β-Receptor-3 (TGFR-3)". PLOS ONE. 8 (6): e67214. Bibcode:2013PLoSO...867214D. doi:10.1371/journal.pone.0067214. PMC 3695229. PMID 23826237. PDB: 4AJV​
  9. ^ a b Bokhove M, Nishimura K, Brunati M, Han L, de Sanctis D, Rampoldi L, Jovine L (2016). "A structured interdomain linker directs self-polymerization of human uromodulin". Proc. Natl. Acad. Sci. U.S.A. 113 (6): 1552–1557. Bibcode:2016PNAS..113.1552B. doi:10.1073/pnas.1519803113. PMC 4760807. PMID 26811476. PDB: 4WRN, 5BUP​
  10. ^ Bokhove M, Jovine L (2018). "Structure of Zona Pellucida Module Proteins". Curr. Top. Dev. Biol. Current Topics in Developmental Biology. 130: 413–442. doi:10.1016/bs.ctdb.2018.02.007. ISBN 9780128098028. PMID 29853186.
  11. ^ Saito T, Bokhove M, Croci R, Zamora-Caballero S, Han L, Letarte M, de Sanctis D, Jovine L (2017). "Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1". Cell Reports. 19 (9): 1917–1928. doi:10.1016/j.celrep.2017.05.011. PMC 5464963. PMID 28564608. PDB: 5HZV​
  12. ^ Stsiapanava A, Xu C, Brunati M, Zamora-Caballero S, Schaeffer C, Bokhove M, Han L, Hebert H, Carroni M, Yasumasu S, Rampoldi L, Wu B, Jovine L (2020). "Cryo-EM structure of native human uromodulin, a zona pellucida module polymer". EMBO J. 39 (24): e106807. doi:10.15252/embj.2020106807. PMC 7737619. PMID 33196145. bioRxiv 10.1101/2020.05.28.119206 PDB: 6TQK, 6TQL​
  13. ^ Stsiapanava A, Xu C, Nishio S, Han L, Yamakawa N, Carroni M, Tunyasuvunakool K, Jumper J, de Sanctis D, Wu B, Jovine L (2022). "Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH". Nat. Struct. Mol. Biol. 29 (3): 190–193. doi:10.1038/s41594-022-00729-3. PMC 8930769. PMID 35273390. PDB: 7PFP, 7Q3N​
  14. ^ Callebaut I, Mornon JP, Monget P (2007). "Isolated ZP-N domains constitute the N-terminal extensions of Zona Pellucida proteins". Bioinformatics. 23 (15): 1871–1874. doi:10.1093/bioinformatics/btm265. PMID 17510169.
  15. ^ Raj I, Sadat Al Hosseini H, Dioguardi E, Nishimura K, Han L, Villa A, de Sanctis D, Jovine L (2017). "Structural Basis of Egg Coat-Sperm Recognition at Fertilization". Cell. 169 (7): 1315–1326. doi:10.1016/j.cell.2017.05.033. PMC 5480393. PMID 28622512. PDB: 5II4, 5II5, 5II6, 5MR2, 5IIC, 5IIA, 5IIB, 5MR3​